| Average | .318 | Cristian Yelich (Astros) |
| At Bats | 654 | Bobby Witt Jr. (Monarchs) |
| Runs | 128 | Shohei Ohtani (Rays) |
| Hits | 180 | Bobby Witt Jr. (Monarchs) |
| Doubles | 52 | Bobby Witt Jr. (Monarchs) |
| Triples | 15 | Jung Hoo Lee (Blue Jays) |
| Home Runs | 55 | Cal Raleigh (Astros) |
| Runs Batted In | 139 | Cal Raleigh (Astros) |
| Walks | 101 | Mike Trout (Grays) |
| Strikeouts | | Shohei Ohtani (Rays) |
| Strikeouts | 230 | James Wood (Expos) |
| Hit By Pitch | 34 | Caleb Durbin (Tigers) |
| Sacrifices | 17 | Cedric Mullins (Rays) |
| Stolen Bases | 83 | Chandler Simpson (Giants) |
| GIDP | 23 | Brian Reynolds (Tigers) |
| Slugging Pct. | .644 | Aaron Judge (Astros) |
| On Base Pct. | .421 | Aaron Judge (Astros) |
| Errors | 28 | Augustin Ramirez (Expos) |
| | |
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| Wins | 18 | Nick Pivetta (Giants) |
| Losses | 19 | Logan Allen (Giants) |
| Winning Pct. | .882 | Logan Gilbert (Astros) |
| ERA | 1.70 | Garret Crochet (Braves) |
| Innings Pitched | 231.2 | Logan Webb (Brewers) |
| Games Pitched | 73 | Jeff Hoffman (Expos) |
| Games Started | 38 | Logan Webb (Brewers) |
| Complete Games | 7 | Merrill Kelly (Nationals) |
| Saves | 40 | Andres Munoz (Giants) |
| Shutouts | 3 | Paul Skenes (Giants) |
| Hits Allowed | 224 | Logan Webb (Brewers) |
| Runs Allowed | 118 | Eduardo Rodriguez (Expos) |
| ER Allowed | 115 | Eduardo Rodriguez (Expos) |
| HR Allowed | 45 | Spencer Arighetti (Pirates) |
| BB Allowed | 91 | Carlos Rodon (Athletics) |
| Strikeouts | 268 | Dylan Cease (Giants) |